MIF4G domain-containing protein (SLBP-interacting protein 1, hSLIP1, MIF4GD, SLIP1)

Function

• replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop
• may participate in circularizing those mRNAs specifically enhancing their translation
• interacts with EIF4G1, EIF4G2 & SLBP; probably tethered by SLBP to the 3'-end of mRNAs ending with the histone stem-loop,
• also interacts with EIF4G1 which is bound to their 5'-end

Structure

• belongs to the MIF4GD family
• contains 1 MIF4G domain

Compartment

cytoplasm, nucleus

Alternative splicing

named isoforms=2

Pathology

• depletion of MIF4GD results in cell death & diminished histone mRNA translation

More general terms

• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/A9UHW6.html