ubiquitin carboxyl-terminal hydrolase 17-like protein 2 (ubiquitin thioesterase 17-like protein 2, ubiquitin-specific-processing protease 17-like protein 2, deubiquitinating enzyme 17-like protein 2, deubiquitinating protein 3, DUB-3, USP17L2, DUB3)

Function

• role in cell apoptosis
• cleaves ubiquitin fusion protein substrates

ubiquitin C-terminal thioester + H2O <--> ubiquitin + a thiol

Structure

belongs to the peptidase C19 family, USP17 subfamily

Compartment

nucleus (putative)

Expression

• broadly expressed
• up-regulated by interleukin-4 & interleukin-6

Notes

• the RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of USP17
• it is present with an interindividual variation in copy number & between 20 to 103 copies can be found in the genome both on chromosome 4 & chromosome 8

More general terms

• ubiquitin C-terminal hydrolase
• nuclear protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3776
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3921
• UniProt: http://www.uniprot.org/uniprot/Q6R6M4.html