ubiquitin carboxyl-terminal hydrolase 17; ubiquitin thioesterase 17; ubiquitin-specific-processing protease 17; deubiquitinating enzyme 17; ubiquitin carboxyl-terminal hydrolase 17-like protein 24 (USP17, USP17L24, USP17H, USP17I, USP17J, USP17K, USP17M, USP17L25, USP17L26, USP17L27, USP17L28, USP17L29, USP17L30)

Function

• deubiquitinating enzyme
• removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include:
  • cell proliferation
  • progression through the cell cycle
  • apoptosis
  • cell migration
  • cellular response to viral infection
• thioester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin

Structure

• belongs to the peptidase C19 family, USP17 subfamily

Compartment

• nucleus, nucleolus, endoplasmic reticulum

Expression

• expressed in heart, brain, liver & skeletal muscle

Genetics

• the RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of USP17
  • it is present with an interindividual variation in copy number & between 20 to 103 copies
  • can be found both on chromosome 4 & chromosome 8

More general terms

• ubiquitin C-terminal hydrolase
• nuclear protein

Additional terms

• ubiquitin (UBCEP2, UBB, UBC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=728369
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=728373
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=728379
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=728393
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=728400
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=728405
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=728419
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:728369
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:728373
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:728379
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:728393
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:728400
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:728405
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:728419
• OMIM: https://mirror.omim.org/entry/607011
• UniProt: http://www.uniprot.org/uniprot/Q0WX57.html