PHD finger protein 19 (polycomb-like protein 3, hPCL3, PHF19, PCL3)

Function

• acts as a transcritpional repressor
• isoform 1 & isoform 2 inhibit transcription from an HSV-tk promoter

Structure

contains 2 PHD-type Zn+2 fingers

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

• isoform 1 is expressed in thymus, heart, lung & kidney
• isoform 2 is predominantly expressed in placenta, skeletal muscle & kidney

Pathology

• overexpressed in many types of cancers, including colon, skin, lung, rectal, cervical, uterus, liver cancers, in cell lines derived from different stages of melanoma & in glioma cell lines

More general terms

• nuclear protein
• zinc finger protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2614
• UniProt: http://www.uniprot.org/uniprot/Q5T6S3.html