mediator of RNA polymerase 2 transcription subunit 25 (mediator complex subunit 25, activator-recruited cofactor 92 kD component, ARC92, activator interaction domain 1 protein, p78, MED25, ACID,1 ARC92, PTOV2, TCBAP0758)

Function

• component of the mediator complex
• interacts with CREBBP.
• interacts with ESR1, GR, RARA, RXRA & THRB (ligand-dependent)
• binds the Herpes simplex virus activator VP16

Structure

belongs to the mediator complex subunit 25 family

Compartment

nucleus

Alternative splicing

named isoforms=5

Expression

• ubiquitously expressed
• highest levels in brain, heart, kidney, peripheral leukocytes, placenta, skeletal muscle & spleen

More general terms

• nuclear protein

Component of

• mediator complex (mediator of RNA polymerase 2 transcription)

Database

• UniProt: http://www.uniprot.org/uniprot/Q71SY5.html