synaptonemal complex central element protein 1 (SYCE1, C10orf94)

Function

• major component of the transverse central element of synaptonemal complexes
• requires SYCP1 in order to be incorporated into the central element
• role in synaptonemal complex assembly, stabilization & recombination (putative)
• found in a complex with SYCP1 & SYCE2
• interacts with SYCP1 & SYCE2 (putative)

Structure

• homodimer
• belongs to the SYCE family

Compartment

• nucleus, associates with chromatin
• in prophase 1 stage of meiosis, localizes in the transverse central elements of the central region between lateral elements of the synaptonemal complexes
• found only where the chromosome cores are synapsed
• colocalizes with SYCE2 in the central elements

Alternative splicing

named isoforms=3

More general terms

• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8N0S2.html