synaptonemal complex protein 1; SCP-1; cancer/testis antigen 8; CT8 (SYCP1, SCP1)

Function

• major component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase
• found in a complex with SYCE1 & SYCE2
• interacts with SYCE1 & SYCE2 (putative)

Structure

• consists of an alpha-helical stretch of 700 AA residues, flanked by N- & C-terminal globular domains
• the C-terminal domain has DNA-binding capacity (putative)

Compartment

• nucleus (putative)
• in tripartite segments of synaptonemal complexes, between lateral elements in the nucleus
• found only where the chromosome cores are synapsed
• its N-terminus is found towards the center of the synaptonemal complex; the C-terminus extends well into the lateral domain of the synaptonemal complex (putative)

Expression

testis

More general terms

• phosphoprotein
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6847
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6847
• OMIM: https://mirror.omim.org/entry/602162
• UniProt: http://www.uniprot.org/uniprot/Q15431.html