transforming growth factor beta regulator 1 (nuclear interactor of ARF & Mdm2, TBRG1, NIAM)

Function

• acts as a growth inhibitor
• can activate TP53/p53, causes G1 arrest & collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis
• redistributes CDKN2A into the nucleoplasm
• role in maintaining chromosomal stability
• interacts with CDKN2A & MDM2
• ubiquitination mediated by MDM2 leads to proteasomal degradation

Structure

• belongs to the TBRG1 family
• contains 1 FY-rich C-terminal domain
• contains 1 FY-rich N-terminal domain

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

• widely expressed at low levels in most tissues
• highest levels in pancreas, lung & liver

Pathology

• expression is decreased in primary tumors including lung cancer, hepatocellular carcinoma, breast cancer, pancreatic cancer, renal cell carcinomas, chronic lymphocytic leukemia & diffuse large B-cell lymphoma

More general terms

• nuclear protein

Additional terms

• transforming growth factor beta regulator (TBRG)

Database

• UniProt: http://www.uniprot.org/uniprot/Q3YBR2.html