RAD51-associated protein 1 (RAD51-interacting protein, RAD51AP1, PIR51)

Function

• role in DNA damage response pathway associated with activation of homologous recombination & DNA double-strand break repair
• binds to single & double stranded DNA
• capable of aggregating DNA
• binds RNA
• isoform 2 interacts with RAD51

Compartment

• nucleus
• colocalizes with RAD51 to multiple nuclear foci

Alternative splicing

named isoforms=3

Expression

• highly expressed in testis & thymus
• lower levels in colon & small intestine
• little or no expression in spleen, prostate, ovary, peripheral blood leukocytes

More general terms

• nuclear protein

Additional terms

• RAD51-associated protein 2 (RAD51AP2)

Database

• OMIM: https://mirror.omim.org/entry/603070
• UniProt: http://www.uniprot.org/uniprot/Q96B01.html