factor IX complex

Introduction

Tradenames: Konyne 80, Proplex T.

Indications

• to control bleeding in patients with factor IX deficiency (hemophilia B or Christmas disease)
• prevention of control of bleeding in hemophilia A patients with inhibitors to factor VIII

Contraindications

• liver disease with signs of intravascular coagulation or fibrinolysis
• not for use in patients with factor VII deficiency

Caution:

• use with caution in patients with liver dysfunction
• risk of viral transmission

Dosage

• individualize dosage (IV)
• based upon factor IX units

Single dose vials with various units.

Adverse effects

• not common (1-10%)
  • transient fever/chills, headache, flushing, tingling following rapid administration
• uncommon (< 1%)
  • disseminated intravascular coagulation (DIC), thrombosis following high doses, somnolence, urticaria, tightness in chest & neck

Drug interactions

• increased incidence of thrombosis with aminocaproic acid

More general terms

• transfusion component

Additional terms

• coagulation factor IX; Christmas factor; plasma thromboplastin component; PTC; contains: coagulation factor IXa light chain; coagulation factor IXa heavy chain (F9)
• Factor Ix Parenteral