metastasis-associated protein MTA3 (MTA3, KIAA1266)

Function

• role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription (histone deacetylase dependent), & thus regulation of E-cadherin levels
• component of the nucleosome-remodeling & histone-deacetylase multiprotein complex (NuRD complex)

Structure

• contains 1 BAH domain
• contains 1 ELM2 domain
• contains 1 GATA-type Zn+2 finger
• contains 1 SANT domain

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• expressed in epithelial cells
• no expression in nonepithelial cells
• induced by estrogen

More general terms

• zinc finger protein
• nuclear protein

Additional terms

• histone deacetylase
• metastasis

Component of

• nucleosome remodeling & histone deacetylation (NuRD) complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57504
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:57504
• OMIM: https://mirror.omim.org/entry/609050
• UniProt: http://www.uniprot.org/uniprot/Q9BTC8.html