zinc finger protein SNAI1; protein snail homolog 1; protein sna (SNAI1, SNAH)

Function

• seems to be involved in embryonic mesoderm formation
• binds to 3 E-boxes of the E-cadherin gene promoter & represses its transcription

Structure

• belongs to the snail C2H2-type Zn+2-finger protein family
• contains 4 C2H2-type Zn+2 fingers

Compartment

• nucleus (putative)

Expression

• expressed in a variety of tissues
• highest expression in kidney

Comparative biology

• in Drosophila, required for mesoderm formation
• acts as boundary repressor by downregulating expression of ectodermal genes in mesoderm

More general terms

• snail protein homolog
• C2H2 type zinc finger protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6615
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6615
• OMIM: https://mirror.omim.org/entry/604238
• UniProt: http://www.uniprot.org/uniprot/O95863.html