MAD2L1-binding protein; caught by MAD2 protein (MAD2L1BP, CMT2, KIAA0110)

Function

• may function to silence the spindle checkpoint & allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex
• phosphorylated upon DNA damage, probably by ATM or ATR
• interacts with MAD2L1

Structure

belongs to the MAD2L1BP family

Compartment

• nucleus, cytoplasm, cytoskeleton, spindle
• during early mitosis, unevenly distributed throughout the nucleoplasm
• from metaphase to anaphase, concentrated on the spindle

Expression

• during the cell cycle, levels increase & then remain constant until late mitosis after which they drop

More general terms

• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9587
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9587
• UniProt: http://www.uniprot.org/uniprot/Q15013.html