Mdm4 protein; Mdm2-like p53-binding protein; Mdmx protein; double minute 4 protein (MDM4, MDMX)

Function

• inhibits p53- & p73-mediated cell cycle arrest & apoptosis by binding its transcriptional activation domain
• inhibits degradation of MDM2
• can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation & apoptotic functions
• binds to p53, p73 & MDM2

Structure

• region I
  • sufficient for binding p53 & inhibiting its G1 arrest & apoptosis function
  • also binds p73
• region II
  • contains most of a central acidic region
  • contains a putative C4-type Zn+2 finger
• RING finger domain
  • coordinates 2 Zn+2
  • mediates the heterooligomerization with MDM2
• belongs to the MDM2/MDM4 family
• contains 1 RanBP2-type Zn+2 finger
• contains 1 RING-type Zn+2 finger
• contains 1 SWIB domain
• mass spec: mass=54863.3; method=MALDI; Range=1-490

Compartment

nucleus

Expression

• expressed all tissues tested
• high levels in thymus

More general terms

• nuclear protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4194
• OMIM: https://mirror.omim.org/entry/602704
• UniProt: http://www.uniprot.org/uniprot/O15151.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4194