trimethylguanosine synthase; CLL-associated antigen KW-2; Cap-specific guanine-N2 methyltransferase; hepatocellular carcinoma-associated antigen 137; nuclear receptor coactivator 6-interacting protein; PRIP-interacting protein with methyltransferase motif; PIMT; PIPMT (TGS1, HCA137, NCOA6IP, PIMT)

Function

• methyltransferase (putative)
• binds S-adenosyl-L-methionine & RNA
• transcriptional regulation
• interacts with NCOA6, CREBBP, EP300, PPARBP, SMN

Kinetic parameters:

• KM=30 uM for m(7)GDP
• KM=5 uM for S-adenosyl-L-methionine
• pH dependence: optimum pH is 8.5-9.5

Structure

may form homooligomers

Compartment

nucleus

Expression

• ubiquitously expressed
• high expression in heart, skeletal muscle, kidney, liver, placenta

More general terms

• methyltransferase
• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=96764
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:96764
• OMIM: https://mirror.omim.org/entry/606461
• UniProt: http://www.uniprot.org/uniprot/Q96RS0.html