bifunctional polynucleotide phosphatase/kinase; polynucleotide kinase-3'-phosphatase; DNA 5'-kinase/3'-phosphatase [includes: polynucleotide 3'-phosphatase, 2'(3')-polynucleotidase, polynucleotide 5'-hydroxyl-kinase] (PNKP)

Function

• catalyzes phosphorylation of DNA at 5'-OH
• can also dephosphorylate its 3'-phosphate
• plays a role in DNA repair following ionizing radiation or oxidative damage

Expression

• highest expression in spleen & testis
• lowest expression in small intestine

More general terms

• nuclear protein
• phosphomonoesterase
• kinase or ATP-phosphotransferase

Database

• OMIM: https://mirror.omim.org/entry/605610
• UniProt: http://www.uniprot.org/uniprot/Q96T60.html