dual specificity protein phosphatase CDC14A; CDC14 cell division cycle 14 homolog A (CDC14A)

Function

• dual-specificity phosphatase
• required for centrosome separation & productive cytokinesis during cell division
• may dephosphorylate the cyclosome subunit FZR1/CDH1, thus promoting cyclosome-FZR1 dependent degradation of mitotic cyclins & subsequent exit from mitosis
• interacts with KIF20A, which is required to localize CDC14 to the midzone of the mitotic spindle

Structure

• composed of two structurally equivalent A & B domains that adopt a dual specificity protein phosphatase (DSP) fold
• belongs to the protein-tyrosine phosphatase family non-receptor class CDC14 subfamily

Compartment

• nucleus, cytoplasm, cytoskeleton, centrosome
• cytoskeleton, spindle
• centrosomal during interphase
• released into the cytoplasm at the onset of mitosis
• subsequently localizes to the midzone of the mitotic spindle

Alternative splicing

named isoforms=4

More general terms

• dual specificity phosphatase
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8556
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8556
• OMIM: https://mirror.omim.org/entry/603504
• UniProt: http://www.uniprot.org/uniprot/Q9UNH5.html