histone-lysine N-methyltransferase, H3 lysine-79 specific; DOT1-like protein; histone H3-K79 methyltransferase; H3-K79-HMTase; lysine N-methyltransferase 4 (DOT1L, KIAA1814, KMT4)

Function

• histone N-methyltransferase
• methylates Lys-79 of histone H3
• nucleosomes are preferred as substrate compared to free histones
• binds to DNA
• interacts with MLLT10

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]

Structure

• belongs to the DOT1 family
• in contrast to other lysine histone N-methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of Lys of histones

Compartment

nucleus (probable)

Alternative splicing

named isoforms=2

More general terms

• N-methyltransferase
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84444
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84444
• OMIM: https://mirror.omim.org/entry/607375
• UniProt: http://www.uniprot.org/uniprot/Q8TEK3.html