STE20/SPS1-related proline-alanine-rich protein kinase; ste-20-related kinase; DCHT; serine/threonine protein kinase 39 (STK39, SPAK)

Function

• may act as a mediator of stress-activated signals
• phosphorylated form forms a complex with WNK2

Structure

• PAPA box (proline-alanine repeats) may target the kinase to a specific subcellular location by facilitating interaction with intracellular proteins such as actin or actin-like proteins
• belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
• contains 1 protein kinase domain

Compartment

• cytoplasm, nucleus (probable)
• nucleus when caspase-cleaved (probable)

Expression

• expressed in brain & pancreas > heart, lung, kidney, skeletal muscle, liver, placenta & testis

More general terms

• serine/threonine kinase
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27347
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:27347
• OMIM: https://mirror.omim.org/entry/607648
• UniProt: http://www.uniprot.org/uniprot/Q9UEW8.html