Fanconi anemia group G protein; protein FACG; DNA repair protein XRCC9 (FANCG, XRCC9)

Function

• DNA repair protein
• postreplication repair
• cell cycle checkpoint function
• interstrand DNA cross-link repair
• maintenance of normal chromosome stability
• possible tumor suppressor
• component of FA complex

Structure

contains 4 TPR repeats

Compartment

• nucleus, cytoplasm
• the major form is nuclear
• the minor form is cytoplasmic

Expression

• highly expressed in testis & thymus
• found in lymphoblasts

Pathology

• defects in FANCG are a cause of Fanconi anemia (FA)
• the FA complex of which FANCG is a subunit is not found or is non functional in patients with Fanconi anemia

More general terms

• nuclear protein

Component of

• Fanconi anemia complementation group complex (FA complex)

Database

• UniProt: http://www.uniprot.org/uniprot/O15287.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2189
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2189
• OMIM: https://mirror.omim.org/entry/227650
• OMIM: https://mirror.omim.org/entry/602956