RNA polymerase 2 p19 kD subunit (RPB7, RNA polymerase 2 subunit G, POLR2G)

Function

• component of the RNA polymerase 2 complex
• POLR2G is part of a subcomplex with POLR2D that binds to a pocket formed by POLR2A, POLR2B & POLR2F at the base of the clamp element. The POLR2D-POLR2G subcomplex seems to lock the clamp via POLR2D in the closed conformation thus preventing double stranded DNA to enter the active site cleft
• the POLR2D-POLR2G subcomplex
  • protrudes from the RNA polymerase 2 core complex
  • binds single-stranded DNA & RNA

Structure

• belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family

Compartment

nucleus

More general terms

• rna polymerase subunit
• nuclear protein

Component of

• RNA polymerase-2

Database

• UniProt: http://www.uniprot.org/uniprot/P62487.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5436
• OMIM: https://mirror.omim.org/entry/602013