DNA-directed RNA polymerase III subunit RPC8; RNA polymerase III subunit C8; DNA-directed RNA polymerase III subunit H; RNA polymerase III 22.9 kD subunit; RPC22.9 (POLR3H, KIAA1665, RPC8)

Function

• specific peripheral component of RNA polymerase 3
• role in sensing & limiting infection by intracellular bacteria & DNA viruses
• acts as nuclear & cytosolic DNA sensor involved in innate immune response. can sense non-self dsDNA that serves as template for transcription into dsRNA
• the non-self RNA polymerase 3 transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type 1 interferon & NF- Kappa-B through the RIG-I pathway (putative)
• interacts with CRCP/RPC9
• POLR3H/RPC8 & CRCP/RPC9 probably form an RNA polymerase 3 subcomplex

Structure

• belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family

Compartment

nucleus

Alternative splicing

named isoforms=2

More general terms

• nuclear protein
• protein subunit

Component of

• RNA polymerase 3

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=171568
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:171568
• UniProt: http://www.uniprot.org/uniprot/Q9Y535.html