RNA polymerase 2 p16 kD subunit (RPB4, RNA polymerase 2 subunit D, POLR2D)

Function

• component of the RNA polymerase 2 complex
• POLR2D is part of a subcomplex with POLR2G that binds to a pocket formed by POLR2A, POLR2B & POLR2F at the base of the clamp element. The POLR2D-POLR2G subcomplex seems to lock the clamp via POLR2D in the closed conformation thus preventing double stranded DNA to enter the active site cleft
• the POLR2D-POLR2G subcomplex
  • protrudes from the RNA polymerase 2 core complex
  • binds single-stranded DNA & RNA

Structure

• belongs to the eukaryotic RPB4 RNA polymerase subunit family

Compartment

nucleus (putative)

More general terms

• rna polymerase subunit
• nuclear protein

Component of

• RNA polymerase-2

Database

• UniProt: http://www.uniprot.org/uniprot/O15514.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5433
• OMIM: https://mirror.omim.org/entry/606017