melanoma-derived growth regulatory protein; melanoma inhibitory activity protein (MIA)

Function

• inhibits growth of melanoma cells in vitro
• inhibits growth of other neuroectodermal tumors, including gliomas

Structure

• may possess 2 intramolecular disulfide bonds
• belongs to the MIA/OTOR family
  • contains 1 SH3 domain

Compartment

secreted

Pathology

• expressed in malignant melanoma cell lines
• infrequently expressed in glioma cell lines

Laboratory

• melanoma inhibitory activity protein in serum/plasma

More general terms

• secreted protein

Additional terms

• melanoma
• melanoma inhibitory activity protein 2 (MIA2)
• melanoma inhibitory activity protein 3 (protein TANGO, C219-reactive peptide, D320, MIA3, KIAA0268, UNQ6077/PRO20088)

Database

• OMIM: https://mirror.omim.org/entry/601340
• UniProt: http://www.uniprot.org/uniprot/Q16674.html