secreted Ly-6/uPAR-related protein 1; SLURP-1; ARS component B; ARS(component B)-81/S; anti-neoplastic urinary protein; ANUP (SLURP1 ARS)

Function

• has antineoplastic activity
• found to be a marker of late differentiation of the skin
• implicated in maintaining the physiological & structural integrity of the keratinocyte layers of the skin

Structure

• homodimer
• contains 1 UPAR/Ly6 domain

Compartment

secreted

Expression

• expressed granulocytes.
• expressed in skin
• predominantly expressed in the granular layer of skin, notably the acrosyringium
• identified in sweat, saliva, tears, plasma & urine
• regulated by retinoic acid, EGF & IFN-gamma

Pathology

• mutations associated with Meleda disease

More general terms

• secreted protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57152
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:57152
• OMIM: https://mirror.omim.org/entry/248300
• OMIM: https://mirror.omim.org/entry/606119
• UniProt: http://www.uniprot.org/uniprot/P55000.html