poly(U)-specific endoribonuclease; placental protein 11; PP11; protein endoU; uridylate-specific endoribonuclease (ENDOU)

Function

• endoribonuclease that cleaves single-stranded RNAs at uridylates & releases products that have 2'-3'-cyclic phosphate termini

Cofactor: Mn+2

Structure

• monomer (putative)
• belongs to the ENDOU family
• contains 2 SMB (somatomedin-B) domains
  • the active SMB domain may have disulfide bond variability

Compartment

secreted (putative)

Alternative splicing

named isoforms=3

Expression

• placental-specific
• also expressed in various malignant neoplasms

Notes

• originally thought to be a serine protease

More general terms

• endoribonuclease
• secreted protein
• placental protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8909
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8909
• OMIM: https://mirror.omim.org/entry/606720
• UniProt: http://www.uniprot.org/uniprot/P21128.html