hedgehog family protein

Introduction

Homologs of hedgehog, a secreted protein involved in establishing cell fate at several points in Drosophila development.

Function

• role in cell cycle progression
• hedgehog targets include wnt family proteins (Drosophila wingless) & TGF-beta family proteins (Drosophila decapentaplegic)
• hedgehog signalling promotes transcription of cyclin E & cyclin D during Drosophila development
• cilia may play a role in hedgehog signalling

Pathology

• disruption of hedgehog signalling is associated with congenital anomalies of the CNS & other organ systems
• activating mutations can result in some skin cancers, including basal cell carcinoma
• activation of the hedgehog signalling pathway has been associated with tumorigenesis
• tumor cells may induce hedgehog signalling in noncancerous stromal cells that surround the tumor

Pharmacology

• glasdegib (Daurismo) an inhibitor of hedgehog signaling is used to treat acute myeloid leukemia

More general terms

• secreted protein

More specific terms

• desert hedgehog protein; DHH; HHG-3; contains: desert hedgehog protein N-product, desert hedgehog protein C-product (DHH)
• indian hedgehog protein; IHH; HHG-2; contains: indian hedgehog protein N-product, indian hedgehog protein C-product (IHH)
• Sonic hedgehog protein; SHH; HHG-1; contains: sonic hedgehog protein N-product, sonic hedgehog protein C-product (SHH)

Additional terms

• hedgehog interacting protein (HHIP, UNQ5825/PRO1964)
• skinny hedgehog protein