hedgehog family protein
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Introduction
Homologs of hedgehog, a secreted protein involved in establishing cell fate at several points in Drosophila development.
Function
- role in cell cycle progression
- hedgehog targets include wnt family proteins (Drosophila wingless) & TGF-beta family proteins (Drosophila decapentaplegic)[1]
- hedgehog signalling promotes transcription of cyclin E & cyclin D during Drosophila development[2]
- cilia may play a role in hedgehog signalling[3]
Pathology
- disruption of hedgehog signalling is associated with congenital anomalies of the CNS & other organ systems
- activating mutations can result in some skin cancers, including basal cell carcinoma
- activation of the hedgehog signalling pathway has been associated with tumorigenesis[4]
- tumor cells may induce hedgehog signalling in noncancerous stromal cells that surround the tumor[4]
Pharmacology
- glasdegib (Daurismo) an inhibitor of hedgehog signaling is used to treat acute myeloid leukemia
More general terms
More specific terms
- desert hedgehog protein; DHH; HHG-3; contains: desert hedgehog protein N-product, desert hedgehog protein C-product (DHH)
- indian hedgehog protein; IHH; HHG-2; contains: indian hedgehog protein N-product, indian hedgehog protein C-product (IHH)
- Sonic hedgehog protein; SHH; HHG-1; contains: sonic hedgehog protein N-product, sonic hedgehog protein C-product (SHH)
Additional terms
References
- ↑ Jump up to: 1.0 1.1 Bale AE. Hedgehog signaling and human disease. Annu Rev Genomics Hum Genet. 2002;3:47-65. Epub 2002 Apr 15. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12142354
- ↑ Jump up to: 2.0 2.1 Duman-Scheel M, Weng L, Xin S, Du W. Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E. Nature. 2002 May 16;417(6886):299-304. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12015606
- ↑ Jump up to: 3.0 3.1 Marigo V et al. Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog. Genomics. 1995 Jul 1;28(1):44-51. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7590746
- ↑ Jump up to: 4.0 4.1 4.2 Yauch RL et al. A paracrine requirement for hedgehog signalling in cancer. Nature 2008 Sep 18; 455:406. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18754008
- ↑ UniProt http://www.uniprot.org/uniprot/Q9UG01.html