crooked neck-like protein 1 (crooked neck homolog, hCrn, CRNKL1, CRN, CGI-201, MSTP021)

Function

• role in pre-mRNA splicing process
• identified in the spliceosome C complex (isoform 2 predominant)

Structure

• belongs to the crooked-neck family
• contains 17 HAT repeats

Compartment

• nuclear speckle, cytoplasm
• colocalizes with core spliceosomal snRNP proteins
• diffusely expressed in cytoplasm

Alternative splicing

named isoforms=5

Expression

• widely expressed
• highly expressed in testis
• not expressed in brain & lung

Notes

• may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

More general terms

• protein subunit

Component of

• spliceosome C complex

Database

• UniProt: http://www.uniprot.org/uniprot/Q9BZJ0.html