protein S100-A10; S100 Ca+2-binding protein A10; calpactin-1 light chain; calpactin I light chain; p10 protein; p11; cellular ligand of annexin II (S100A10, ANX2LG, CAL1L, CLP11)

Function

• light subunit of calpactin 1
• because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation; the ANXA2 monomer is the preferred target (in vitro) of tyrosine kinase(s)
• does not appear to bind Ca+2
• interacts with SCN10A

Structure

• contains 2 ancestral Ca+2 site related to EF-hand domains that have lost their ability to bind Ca+2
• belongs to the S-100 family

More general terms

• protein subunit
• phosphoprotein

Component of

• calpactin 1

Database

• UniProt: http://www.uniprot.org/uniprot/P60903.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6281
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6281
• OMIM: https://mirror.omim.org/entry/114085