annexin A2; annexin-2; annexin II; lipocortin II; calpactin I heavy chain; chromobindin-8; p36; protein I; placental anticoagulant protein IV; PAP-IV (ANXA2 ANX2 ANX2L4 CAL1H LPC2D)

Function

• heavy subunit of calpactin 1
• Ca+2-regulated membrane-binding protein
• affinity for Ca+2 is greatly enhanced by anionic phospholipids
• binds two Ca+2 with high affinity
• may be involved in heat-stress response
• heterotetramer containing 2 light chains of S100A10/p11 & 2 heavy chains of ANXA2/p36
• interacts with ATP1B1 & DYSF
• phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface
• may cross-link plasma membrane phospholipids with actin & the cytoskeleton & play a role in exocytosis

Structure

• a pair of annexin repeats may form one binding site for Ca+2 & phospholipid
• belongs to the annexin family
• contains 4 annexin repeats

Compartment

• secreted, extracellular space, extracellular matrix
• basement membrane
• melanosome
• translocated from the cytoplasm to the cell surface through Golgi-independent mechanism

More general terms

• protein subunit
• phosphoprotein
• lipocortin or calpactin
• annexin

Component of

• calpactin 1

Database

• UniProt: http://www.uniprot.org/uniprot/P07355.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=302
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:302
• OMIM: https://mirror.omim.org/entry/151740