SAM domain & HD domain-containing protein 1; dendritic cell-derived IFNG-induced protein; monocyte protein 5 (DCIP,MOP-5, SAMHD1, MOP5)

Structure

• contains 1 HD domain
• contains 1 SAM domain (sterile alpha motif)

Expression

• expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung, peripheral blood leukocytes
• no expression in brain or thymus
• induced by interferon gamma

Genetics

• SAMHD1 variants are associated with extended reproductive lifespan in women & increased all-cause cancer risk in both men & women
  • cancers include prostate cancer in men, mesothelioma in both men & women, & suggestive evidence for higher breast cancer susceptibility in women
  • average age of natural menopause extended 1.35 years

More general terms

• other protein

Database

• OMIM: https://mirror.omim.org/entry/606754
• UniProt: http://www.uniprot.org/uniprot/Q9Y3Z3.html