steroid receptor RNA activator 1 (steroid receptor RNA activator protein, SRAP, SRA1)

Function

• functional mRNA also able to encode a protein
• acts as transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand- independently via modulating N-terminal domain (AF-1) of steroid receptors
• mediates transcriptional coactivation of steroid receptors (ligand-dependent) via steroid-binding domain (AF-2)
• enhances cellular proliferation & differentiation & promotes apoptosis in vivo
• role in tumorigenesis
• SRA1 RNA exists in a ribonucleoprotein complex containing NCOA1
• RNA also forms a complex with PUS1 & RARG in the nucleus
• interacts with AR

Compartment

nucleus, cytoplasm

Alternative splicing

named isoforms=2

Expression

• expressed in liver & skeletal muscle > brain
• expressed in both normal & tumorigenic breast epithelial cell lines

Pathology

• up-regulated in human tumors of the breast, ovary, & uterus

More general terms

• other protein

Database

• OMIM: https://mirror.omim.org/entry/603819
• UniProt: http://www.uniprot.org/uniprot/Q9HD15.html