epsin-2 (EPS-15-interacting protein 2, EPN2, KIAA1065)

Function

• plays a role in the formation of clathrin-coated invaginations & endocytosis
• binds EPS15 via NPF repeat domain
• binds AP-2 & clathrin via DPW repeat domain

Structure

• ubiquitinated
• belongs to the epsin family
• contains 1 ENTH domain (epsin N-terminal homology domain)
  • contains 2 UIM repeats (ubiquitin-interacting motif repeats)

Compartment

clathrin coated vesicles, particularly near Golgi

Alternative splicing

named isoforms=4

Expression

expressed in brain > lung, liver

More general terms

• other protein

Database

• OMIM: https://mirror.omim.org/entry/607263
• UniProt: http://www.uniprot.org/uniprot/O95208.html