chordin-like protein 1 (neuralin-1, ventroptin, neurogenesin-1, CHRDL1, NRLN1)

Function

• antagonizes function of BMP-4 (putative)
  • binds BMP-4
  • prevents its interaction with receptors
• alters commitment of neural stem cells from gliogenesis to neurogenesis
• neuronal differentiation of neural stem cells in brain
  • facilitates neuron rather than glial differentiation
• dorsoventral axis formation
• embyonic bone formation

Structure

• contains 3 VWFC domains

Compartment

secreted

More general terms

• other protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9BU40.html