suppressor of T-cell receptor signaling 1; Sts-1; Cbl-interacting protein p70 (STS1, UBASH3B, KIAA1959)

Function

• interferes with CBL-mediated down-regulation & degradation of receptor-type tyrosine kinases
• promotes accumulation of activated target receptors, i.e. T-cell receptor & EGFR, on the cell surface.
• interacts with CBL
• part of a complex containing CBL & activated EGFR
• interacts with ubiquitin & with mono-ubiquitinated proteins

Structure

• contains 1 SH3 domain
• contains 1 UBA domain

Compartment

cytoplasm, nucleus

More general terms

• other protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8TF42.html