deleted in lung & esophageal cancer protein 1; deleted in lung cancer protein 1; DLC-1 (DLEC1, DLC1)

Function

• may act as a tumor suppressor by inhibiting cell proliferation

Compartment

cytoplasm

Alternative splicing

• named isoforms=3
• at least 6 differentially spliced products may exist
• specific splice isoform may be increased in cancer cell lines & primary cancers

Expression

• expressed in all tissues examined
• expression is highest in prostate & testis

Pathology

• DLEC1 silencing due to promoter methylation & aberrant transcription are implicated in the development of different cancers, including esophageal cancer, renal cell carcinoma & lung cancer
• defects in DLEC1 are a cause of lung cancer
  • DLEC1 silencing due to promoter methylation & aberrant transcription are implicated in the development of lung cancer
• defects in DLEC1 are a cause of esophageal cancer
  • DLEC1 silencing due to promoter methylation & aberrant transcription are implicated in the development of esophageal cancer

More general terms

• other protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9940
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9940
• OMIM: https://mirror.omim.org/entry/133239
• OMIM: https://mirror.omim.org/entry/211980
• OMIM: https://mirror.omim.org/entry/604050
• UniProt: http://www.uniprot.org/uniprot/Q9Y238.html