clot lysis time
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Reference interval
- whole blood: lysis in 48-72 hours[2]
- Thompson: lysis in 2-7 hours[2]
- euglobulin: lysis > 60 minutes[1]
Clinical significance
- lysis in < 24 hours indicates significant fibrinolysis
- lysis in < 2 hours indicates severe fibrinolysis
Increases
Decreases
- fibrinolysis*
- fibrinolytic therapy
- chronic liver disease (50% of patients)
- alpha-2 plasmin* May be normal in DIC if plasminogen has been depleted.. inhibitor[3]
* May be normal in DIC if plasminogen has been depleted
Specimen
- whole clotted blood (37 degrees C)
- diluted whole blood (Thompson)
Interferences
- affected by plasma levels of:
- if fibrinogen is < 50 mg/dL, clot may be difficult to see
More general terms
References
- ↑ Jump up to: 1.0 1.1 Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
- ↑ Jump up to: 2.0 2.1 2.2 Clinical Guide to Laboratory Tests, 3rd edition, NW Tietz ed, WB Saunders, Philadelphia, 1995
- ↑ Jump up to: 3.0 3.1 Harrison's Principles of Internal Medicine, 13th ed. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 322