gamma-interferon-inducible lysosomal thiol reductase; gamma-interferon-inducible protein IP-30 (IFI30 GILT)

Function

• cleaves disulfide bonds in proteins by reduction
• may facilitate the complete unfolding of proteins destined for lysosomal degradation
• may be involved in MHC class II-restrictedantigen processing

Structure

• N-glycosylated
• sugar chains contain mannose-6-phosphate
• belongs to the GILT family

Compartment

lysosome

Expression

• expressed constitutively in antigen-presenting cells
• induced by IFN-gamma in other cell types

More general terms

• oxidoreductase
• glycoprotein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/604664
• UniProt: http://www.uniprot.org/uniprot/P13284.html