tyrosine-protein kinase STYK1; novel oncogene with kinase domain; protein PK-unique; serine/threonine/tyrosine kinase 1 (STYK1, NOK)

Function

• probable tyrosine protein kinase
• may act by activating both MAP kinase & PI3K pathways

Structure

• belongs to the protein kinase superfamily, tyrosine protein kinase family
• contains 1 protein kinase domain

Compartment

membrane (potential)

Expression

• widely expressed
• highly expressed in brain, placenta & prostate
• undetectable in most normal lung tissue (see Pathology)

Pathology

• transforming capabilities on a variety of cell lines
• when overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs
• expressed in tumor cells such as hepatoma cells LO2, cervix carcinoma cells HeLa, ovary cancer cells Ho8910 & chronic myelogenous leukemia cells K562, but not in other tumor cells such as epidermoid carcinoma (A431)
• widely expressed in lung cancers (see Expression)

More general terms

• tyrosine kinase (protein tyrosine kinase, PTK)
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55359
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55359
• OMIM: https://mirror.omim.org/entry/611433
• UniProt: http://www.uniprot.org/uniprot/Q6J9G0.html