serine/threonine protein kinase MRCK beta; CDC42-binding protein kinase beta; myotonic dystrophy kinase-related CDC42-binding kinase beta; myotonic dystrophy protein kinase-like beta; MRCK beta; DMPK-like beta (CDC42BPB, KIAA1124)

Function

• downstream effector of CDC42 in cytoskeletal reorganization
• regulates actomyosin contractility required for cell invasion, via regulation of MYPT1 & thus MLC2 phosphorylation
• phorbol ester activates resulting in dimerization via N-terminal region & kinase activation by trans- autophosphorylation
• interacts tightly with GTP-bound but not GDP-bound CDC42

Structure

• homodimer & homotetramer via the coiled coil regions
• maintained in an inactive, closed conformation by an interaction between the kinase domain & negative autoregulatory C-terminal coiled-coil
• contains 1 AGC-kinase C-terminal domain
• contains 1 CNH domain
• contains 1 CRIB domain
• contains 1 PH domain
• contains 1 phorbol-ester/DAG-type Zn+2 finger
• contains 1 protein kinase domain

Compartment

• cytoplasmic, with dispersed punctate distribution, concentrating along the cell periphery, especially at the leading edge & cell-cell junction

Expression

ubiquitously expressed

More general terms

• serine/threonine kinase
• oligomerizing protein
• zinc finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9578
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9578
• OMIM: https://mirror.omim.org/entry/614062
• UniProt: http://www.uniprot.org/uniprot/Q9Y5S2.html