lymphokine-activated killer T-cell-originated protein kinase; cancer/testis antigen 84; CT84; MAPKK-like protein kinase; Nori-3; PDZ-binding kinase; spermatogenesis-related protein kinase; SPK; T-LAK cell-originated protein kinase (PBK, TOPK)

Function

• phosphorylates MAP kinase p38
• active only in mitosis
• may play a role in the activation of lymphoid cells
• activated by phosphorylation (putative)
• phosphorylated; in a cell-cycle dependent manner at mitosis
• interacts with DLG1 & TP53

Structure

• belongs to the protein kinase superfamily, Ser/Thr
• protein kinase family, MAP kinase kinase subfamily
• contains 1 protein kinase domain

Expression

• expressed in the testis & placenta
• in the testis, restrictedly expressed in outer cell layer of seminiferous tubules

Pathology

• when phosphorylated, forms a complex with TP53, leading to TP53 destabilization & attenuation of G2/M checkpoint during doxorubicin-induced DNA damage

More general terms

• serine/threonine kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55872
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55872
• OMIM: https://mirror.omim.org/entry/611210
• UniProt: http://www.uniprot.org/uniprot/Q96KB5.html