serine/threonine-protein kinase/endoribonuclease IRE2; endoplasmic reticulum-to-nucleus signaling 2; inositol-requiring protein 2; hIRE2p; Ire1-beta; IRE1b; includes: serine/threonine-protein kinase; endoribonuclease (ERN2, IRE2)

Function

• pro-apoptotic
• induces translational repression through 28S ribosomal RNA cleavage in response to ER stress.
• no role in the unfolded-protein response

Structure

• kinase domain is activated by trans-autophosphorylation
• kinase activity is required for activation of the endoribonuclease domain

Compartment

• endoplasmic reticulum membrane
• single-pass type 1 membrane protein

More general terms

• serine/threonine kinase
• endoribonuclease

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10595
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10595
• OMIM: https://mirror.omim.org/entry/604034
• UniProt: http://www.uniprot.org/uniprot/Q76MJ5.html