serine/threonine protein kinase SIK2; Qin-induced kinase; salt-inducible protein kinase 2; SIK-2; serine/threonine-protein kinase SNF1-like kinase 2 (SIK2, KIAA0781, QIK, SNF1LK2)

Function

• phosphorylates Ser-794 of IRS1 in insulin-stimulated adipocytes, potentially modulating efficiency of insulin signal transduction
• inhibits CREB activity by phosphorylating & repressing TORCs, the CREB-specific coactivators
• activated by phosphorylation on Thr-175
• phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase & CAB39
• interacts with & phosphorylates TORC2/CRTC2

Cofactor: Mg+2

Structure

• belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
• contains 1 protein kinase domain
• contains 1 UBA domain

Compartment

cytoplasm (putative)

More general terms

• serine/threonine kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23235
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23235
• OMIM: https://mirror.omim.org/entry/608973
• UniProt: http://www.uniprot.org/uniprot/Q9H0K1.html