serine/threonine protein kinase DCLK2; CaMK-like CREB regulatory kinase 2; CLICK-II; CLICK2; doublecortin domain-containing protein 3B; doublecortin-like & CAM kinase-like 2; doublecortin-like kinase 2 (DCLK2, DCAMKL2, DCDC3B, DCK2)

Function

• serine/threonine protein kinase
• low Ca2+/CAM affinity & dependence compared to other members of the CaMK family
• may play a role in down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 & retention of TORC2 in the cytoplasm (putative)
• binds to & stabilizes microtubules (putative)
• may be involved in Ca+2-signaling regulating neuronal migration in the developing brain

Structure

• the doublecortin domains are involved in colocalization with microtubules (putative)
• belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
• contains 2 doublecortin domains
• contains 1 protein kinase domain

Compartment

• cytoplasm, cytoskeleton
• colocalizes with microtubules (putative)

Alternative splicing

named isoforms=3

More general terms

• serine/threonine kinase
• doublecortin domain-containing protein (DCDC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=166614
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:166614
• OMIM: https://mirror.omim.org/entry/613166
• UniProt: http://www.uniprot.org/uniprot/Q8N568.html