cyclin-G-associated kinase (GAK)

Function

• associates with cyclin G & CDK5
• seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells

ATP + a protein = ADP + a phosphoprotein

Structure

• belongs to the protein kinase superfamily, Ser/Thr protein kinase family
• contains 1 C2 tensin-type domain
• contains 1 J domain
• contains 1 phosphatase tensin-type domain
• contains 1 protein kinase domain

Compartment

• cytoplasm, perinuclear region
• Golgi, trans-Golgi network
• cell junction, focal adhesion (probable)

Expression

• ubiquitous
• highest in testis
• expression oscillates slightly during the cell cycle, peaking at G1

More general terms

• serine/threonine kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2580
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2580
• OMIM: https://mirror.omim.org/entry/602052
• UniProt: http://www.uniprot.org/uniprot/O14976.html