dual specificity protein phosphatase 23; low-molecular-mass dual-specificity phosphatase 3; LDP-3; VH1-like phosphatase Z (DUSP23, LDP3, VHZ)

Function

• mediates dephosphorylation of proteins phosphorylated on Tyr & Ser/Thr residues
• dephosphorylate MAPK3 in vitro
• activation of JNK & MAPK14

Kinetic parameters:

• KM=1.498 mM for p-nitrophenylphosphate

Structure

• belongs to the protein-tyrosine phosphatase family non-receptor class dual specificity subfamily
• contains 1 tyrosine-protein phosphatase domain

Compartment

cytoplasm, nucleus

Expression

• widely expressed
• expressed in spleen, prostate, colon, adrenal gland, mammary gland, thyroid & trachea > uterus, small intestine, bladder, bone marrow, brain, spinal cord & stomach

More general terms

• serine/threonine phosphatase
• tyrosine phosphatase (protein tyrosine phosphatate, PTP)
• nucleoside diphosphate-linked moiety X motif

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54935
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54935
• UniProt: http://www.uniprot.org/uniprot/Q9BVJ7.html