dipeptidyl peptidase 3; dipeptidyl aminopeptidase III; dipeptidyl arylamidase III; dipeptidyl peptidase III; DPP III (DPP3)

Function

• cleaves Arg-Arg-beta-naphthylamide
• release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity
• also acts on dipeptidyl 2-naphthylamides

Cofactor:

• binds 1 Zn+2 per subunit (putative)

pH dependence: optimum pH is 8.8

Structure

• belongs to the peptidase M49 family

Compartment

cytoplasm

Alternative splicing

• named isoforms=3
• some isoforms may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

More general terms

• dipeptidyl peptidase (DPP)
• aminopeptidase
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10072
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10072
• OMIM: https://mirror.omim.org/entry/606818
• UniProt: http://www.uniprot.org/uniprot/Q9NY33.html