stromal membrane-associated protein 1-like (SMAP1L)

Function

• GTPase activating protein that acts on ARF1
• activates ARF6 in vitro
• role in clathrin-dependent retrograde transport from early endosomes to trans-Golgi (putative)
• interacts with ARF1
• interacts with PICALM & clathrin heavy chains

Structure

contains 1 Arf-GAP domain

Compartment

• cytoplasm
• detected in multiple foci throughout the cytoplasm & in juxtanuclear structures

Alternative splicing

named isoforms=2

More general terms

• ADP-ribosylation factor GTPase activating protein (ARF-GAP)

Database

• UniProt: http://www.uniprot.org/uniprot/Q8WU79.html