Rho GTPase-activating protein RICH2; RhoGAP interacting with CIP4 homologs protein 2; RICH-2; NPC-A-10 (RICH2, ARHGAP44, KIAA0672)

Function

• GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state
• GTPase activitor in vitro for CDC42 & RAC1

Structure

• contains 1 BAR domain
• contains 1 Rho-GAP domain

Expression

• highly expressed in brain
• weakly expressed in other tissues

More general terms

• rho GTPase-activating protein (rho-GAP)

Database

• UniProt: http://www.uniprot.org/uniprot/Q17R89.html