forkhead box protein I1; forkhead-related transcription factor 6; FREAC-6; drosophila forkhead homolog-like 10 (FREAC6, FOXI1)

Function

• transcriptional activator required for the development of normal hearing, sense of balance & kidney function
• required for expression of SLC26A4/PDS, JAG1 & COCH in a subset of epithelial cells & the development of the endolymphatic system in the inner ear
• required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 & the differentiation of intercalated cells in the epithelium of distal renal tubules

Structure

contains 1 fork-head DNA-binding domain

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

expressed in kidney

More general terms

• forkhead family transcription factor

Database

• OMIM: https://mirror.omim.org/entry/601093
• UniProt: http://www.uniprot.org/uniprot/Q12951.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2299